The First Thing
Studies with preprints and journal versions are listed under the earlier preprint date. CQ, a known autophagy inhibitor that is in clinical use, can efficiently ameliorate acute lung injury and dramatically improve the survival rate in mice infected with live avian influenza A H5N1 virus. An update to this paper, including originally excluded patients, confirms the effectiveness of HCQ+AZ on viral clearance and early discharge . Recommends HCQ for prophylaxis in asymptomatic healthcare workers as found effective in-vitro and in-vivo. CQ is known in nanomedicine research for the investigation of nanoparticle uptake in cells, and may have potential for the treatment of COVID-19.